TRACE RA – what is this?
02/05/08: NRAS
TRACE RA – what is this?
Overview...
Rheumatoid arthritis (RA) is associated with increased mortality from cardiovascular disease (CVD). This is thought to be due to accelerated atherosclerotic coronary heart disease (CHD), possibly occurring due to a combination of systemic inflammation augmenting an adverse cardiovascular risk profile.
Statins have a proven beneficial effect in reducing CVD events and mortality in at-risk populations, mostly due to their cholesterol-lowering properties, but also possibly through anti-inflammatory and immunomodulatory effects. Whether such benefit occurs in a high-grade inflammatory condition such as RA remains unknown, because such patients have been systematically excluded from previous statin trials.
Our goal...
This prospective, 5-year, multi-centre, randomised, double blind, placebo-controlled trial will assess the hypothesis that atorvastatin is more effective than placebo in the primary prevention of cardiovascular events in patients with RA*. All patients will receive lifestyle modification advice. Patients already receiving or requiring statin therapy for secondary prevention or whose managing physician thinks they should be on a statin for an existing indication will be excluded.
Sub study...
A nested sub-study (TRACE RA-DAS) will investigate the hypothesis that atorvastatin is more effective than placebo as adjunctive therapy in reducing RA disease activity. Patients enrolled in TRACE RA-DAS will have moderately or severely active disease at the time that they are recruited to the main study.
This trial is supported by: arc - The Arthritis Research Council and the British Heart Foundation
As at 16th April 2008
Centre Summary
Number of Centres expressed a keen interest: 60
Number of Centres with Regulatory Approvals: 34
Number of Centres Initiated: 29
Number of Centres Recruiting: 11
To find out more, please visit: http://www.dgoh.nhs.uk/tracera
To view the latest TRACE RA newsletter click here.
Centres which are currently recruiting or are ready to recruit
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Name of Hospital
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Name of Trust
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Principal Investigator
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Altnagelvin Hospital
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Western Health and Social Care Trust
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Dr Phil Gardiner
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Arrowepark Hospital
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Wirral Hospital NHS Trust
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Dr Emmanuel George
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Aintree University Hospital
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Aintree University Hospitals NHS Foundation Trust
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Dr Nicky Goodson
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Cannock Chase Hospital
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Mid Staffordshire General Hospitals NHS Trust
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Dr Diarmuid Mulherin
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Christchurch Hospital
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Royal Bournemouthand Christchurch Hospitals NHS Foundation Trust
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Dr Neil Hopkinson
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City Hospital
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Sandwell and West Birmingham Hospitals NHS Trust
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Dr Deva Situnayake
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Derby Hospitals NHS Foundation Trust
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Derby Hospitals NHS Foundation Trust
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Dr Chris Deighton
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Freeman Hospital
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Newcastle upon Tyne Hospitals NHS Foundation Trust
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Dr David Walker
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Glasgow Royal Infirmary
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NHS Greater Glasgow and Clyde
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Dr David McCarey
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Haywood Hospital
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University Hospital of North Staffordshire NHS Trust
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Dr Jonathan Packham
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Hemel Hempstead Hospital
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West Hertfordshire Hospitals NHS Trust
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Dr Adam Young
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Ipswich Hospital
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Ipswich Hospital NHS Trust
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Dr Richard Watts
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Kingsmill Hospital
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Sherwood Forest Hospitals NHS Foundation Trust
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Dr David Walsh
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Macclesfield General Hospital
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East Cheshire NHS Trust
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Dr Susan Knight
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Manchester Royal Infirmary
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Central Manchester and Manchester Childrens University Hospital NHS Trust
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Dr Ian Bruce
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Ninewells Hospital
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NHS Tayside
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Dr Tom Pullar
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North Hampshire Hospital
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Basingstoke and North Hampshire NHS Foundation |Trust
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Dr Peter Prouse
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Poole Hospital
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Poole Hospital NHS Foundation Trust
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Dr Selwyn Richards
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Queen's Hospital
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Barking, Havering and Redbridge Hospitals NHS Trust
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Professor Kuntal Chakravarty
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Royal Glamorgan Hospital
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Pontypridd and Rhondda NHS Trust
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Dr Ceril Rhys-Dillon
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Royal Lancaster Infirmary
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University Hospitals of Morecambe Bay NHS Trust
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Dr Marwan Bukhari
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Royal Sussex County Hospital
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Brighton and Sussex University Hospitals NHS Trust
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Dr George Papasavvas
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Russells Hall Hospital
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Dudley Group of Hospitals
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Dr Rainer Klocke
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Selly Oak Hospital
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University Hospital Birmingham NHS Foundation Trust
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Dr Elizabeth Rankin
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Solihull Hospital
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Heart of England NHS Foundation Trust
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Dr Arvind Sinha
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Southend Hospital
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Southend University Hospital NHS Foundation Trust
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Prof Bhaskar Dasgupta
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Southmead Hospital
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North Bristol NHS Trust
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Dr Paul Creamer
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Trafford General Hospital
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Trafford Healthcare NHS Trust
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Dr Frank McKenna
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University Hospitals Coventry and Warwickshire NHS Trust
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University Hospitals Coventry and Warwickshire NHS Trust
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Dr Maggie Allen and Dr Alec Price-Forbes
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University Hospital Durham
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County Durham and Darlington NHS Foundation Trust
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Dr Namita Kumar
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Wexham Park Hospital
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Heatherwood and Wexham Hospitals NHS Foundation Trust
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Dr Matthew Adler
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Withington Community Hospital
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University Hospital South Manchester NHS Foundation Trust
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Dr Paul Sanders
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Worcestershire Hospital
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Worcestershire Acute Hospitals NHS Trust
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Dr Iain Rowe
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